Founded in 2007, P.E.D® was set up to progress research into the root cause/s of laminitis susceptibility and won a BETA International 2010 Innovation Award in the Feeds & Supplements category. Metabolic conditions associated with laminitis are life-threatening and commonly seen worldwide. P.E.D® has identified ‘biomarkers’ for imbalances in the body which occur over time and have progressed ways to measure the imbalances and help maintain health in the horse. This work has led to the formulation of LaminTec 5-HT™, an innovative equine feed supplement maintaining circulatory health.
LaminTec 5-HT™ contains a unique ingredient (feverfew herb) standardised so that the same chemicals of the herb are available in every pot you buy, unlike many other products where the quality varies from tub to tub. Our research shows that serotonin is a key factor in Cushing’s disease; other researchers have also shown that serotonin may constrict the equine digital (hoof) blood vessels. This is important because when platelets are activated, they release serotonin into the blood circulation; feverfew is known to attenuate platelet activating factor. Additionally, parthenolide (a component of feverfew herb) has been shown to help protect equine digital blood vessels.
Breakthrough in laminitis research; could this be the light at the end of the tunnel?
Researchers at P.E.D®, believe susceptibility to laminitis may be detected using ‘biogenic amine biomarkers’; substances in the body which could help predict if a particular horse is prone to the disease. The idea is that balance must be maintained in the horse’s body for it to be healthy and that there are key chemicals involved. Vets and researchers have been questioning for some years whether the current diagnostics (as opposed to pre-emptive) tests are helpful, given that false positives for Cushing’s disease may occur in autumn for normal horses and there are varied results of current treatments connected with laminitis.
The company has analysed the seasonal and daily patterns in equine hormones and neurohormones (ACTH, cortisol, insulin, serotonin, melatonin, dopamine being key) in order to investigate laminitis susceptibility at different times of year. The most significant differences during the year seem to occur in the autumn, which may explain why horses have an increased risk at this time. However, few significant internal changes were found in the spring, therefore raising the question of what is happening inside the horse to make this a high risk period. One suggestion could be the ‘shock’ of large quantities of grass to the bacteria in the hind gut after a winter period without much turnout.
Some of their findings were published in the Journal of Endocrinology in 2008, and The Veterinary Journal in July 2010 click here (insert links) to read the articles. The theories behind the product involve ‘biogenic amine biomarkers’, substances within the body which have been found to be imbalanced during the onset and development of such conditions.”
Pegasus Equine Diagnostics Ltd (PED) has significant welfare interests in the area of equine nutritional supplementation and Nutraceutical research. The company has successfully developed a product for equine laminitis (LaminTec 5-HT) and has launched a new product to support joint and muscles.
The New Product that is now available to purchase is called MoveTec 2-KE which has also been scientifically reviewed, on the success of the research, trials were performed with excellent results, please see reviews as described in MoveTec 2-KE product Sales section of web site.
Background information: Inflammation is a common feature of a range of different musculoskeletal and arthritic diseases in horses. The blended formulations in MoveTec 2-KE contain curcumin and resveratrol, two naturally occurring plant polyphenols that have been shown to inhibit production of NO and PGE2 in cultured equine cells. Nutritional supplementation with these ingredients may help to address lameness and the clinical signs of arthritis while improving joint health.
Our aims are to eradicate pain and suffering in the horse community wherever possible and therefore Pegasus Equine Diagnostics Ltd will continue to research and develop new products for the benefit of equine market.